Back to Ask the Diabetes Team Ask the Diabetes Team

From Louisiana, USA:

If an adult patient with type 2 diabetes who is taking glipizide came to you after two weeks and the blood sugar level was still not well controlled, would the next step be to Increase the dose of glipizide, replace with insulin. or replace with metformin?


It depends. and I don't have enough information. I would need to know the person's age, height and weight, duration of diabetes, blood sugar levels fasting, along with before and after meals, the current dose of glipizide, and their liver and kidney function. All of these factors as well as dietary and activity habits help me decide which would be the best course of action.


Additional comments from Barb Schreiner, diabetes nurse specialist:

Maximize the dose of glipizide, and then add metformin a few weeks later. DeFronzo and others have recommended not stopping one drug and starting another. Rather, use combination therapy with drugs from different classes.


Original posting 9 Aug 2003
Posted to Daily Care and Type 2


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:09:48
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.