From St. Louis, Missouri, USA:
Is it possible to mix Lispro and Regular together, in the same syringe? There have been situations that we felt would be ideal for our 5 year old daughter, where we wanted the more immediate Lispro to lower her sugars from a meal, especially one high in carbs, and then the regular to stick around and cover both protein and longer-to-break-down carbs. We have run into this situation, for example, at family events, parties etc., where she might be eating things we would not normally let her eat, and she would eat a meal, followed by a more sugary dessert than we would normally let her have. We would get really good late coverage with extra Regular, but she would have the immediate postprandial surge. Or, if we used Lispro, we would get lower immediate sugars, but then the blood glucose's would rise after the Lispro had peaked. We especially have noticed this when the occasion was at lunchtime, and it would be very difficult to figure out her morning NPH to have good coverage of the extra meal.
We just wondered if the two insulins had been tested together, and if this made any sense?
Although mixing lispro insulin [Humalog® brand] and Regular together have not been officially studied and approved, there have been several reports in the medical literature evaluating this combination. I am not aware that any adverse affects have been reported. I agree that sometimes the combination of these 2 insulins works better than either alone. Before making any changes, first be sure to discuss them with your child's own physician.
Original posting 1 Feb 98
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