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From Wichita, Kansas, USA:

Does being overweight really add to the cause of diabetes? Why is that?


Obesity increase the likelihood of Type 2 Diabetes and the explanation runs something like this. Fat tissue require about three times as much insulin for basal metabolism as does muscle tissue. Obesity therefore increases the demand for insulin and raises serum insulin levels. This in turn downregulates the insulin receptors (i.e., makes them even more insensitive to insulin). The result of this cycle is an increased demand for insulin production to the point that production is insufficient to keep blood glucose at normal levels. New drugs like troglitazone [Rezulin® brand] are designed to break this chain by increasing receptor sensitivity to insulin. Losing weight of course reduces demand for insulin.


Original posting 9 Mar 97


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Last Updated: Tuesday April 06, 2010 15:08:54
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