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Are there any plans to make more consistent long-lasting insulins, like the NPH and Lente? I realize that certain factors may place a part in the variability such as where you inject and the amount of insulin you are using, but it would be nice to know that the max duration is 14 hours, not 14 - 18 (for the NPH) or that it will start working in 2 hours, not 2 - 4 hours.


We used to have such a product: a long-lasting, reliable insulin that could be injected once a day and get a truly "basal" insulin dose. As you might recall, it was therefore extremely frustrating to all of us, both patients and endocrinologists who used Novo's animal Ultralente (which lasts a day-and-a-half or even more), when Novo abruptly discontinued its production a year or two ago. The longest duration insulin currently available is Lilly's semisynthetic Ultralente, which only lasts a day at most (see What is Insulin?).

Fortunately, the insulin manufacturers are well on the way to developing very long-lasting insulins which should be undergoing clinical trials soon.


Original posting 21 Oct 96


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Last Updated: Tuesday April 06, 2010 15:08:52
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